Measurement of locomotor activity in hyperalgesic rats as an objective method for testing the antialgesic activity of drugs.

ABSTRACT

The registration of locomotor activity in hyperalgesic rats has been shown to be a simple and objective method to demonstrate the antialgesic activity of NSAI. Aspirin-like drugs significantly antagonize the pain-produced reduction in motility of hyperalgesic rats. It has also been demonstrated that new potent anti-inflammatory methanesulfonanilides, which do not inhibit PG-synthesis in vitro and are almost inactive in Writhing models, exhibit potent antialgesic activity in this model.