Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms.

Zelphati, O; Imbach, J L; Signoret, N; Zon, G; Rayner, B; Leserman, L

Zelphati, O; Imbach, J L; Signoret, N; Zon, G; Rayner, B; Leserman, L.

Affiliation

Zelphati O; Centre d'Immunologie, Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique de Marseille-Luminy Case 906, France.

Nucleic Acids Res ; 22(20): 4307-14, 1994 Oct 11.

Article in En | MEDLINE | ID: mdl-7524038

Subject(s)

Antiviral Agents/pharmacology; HIV-1/physiology; Immunotoxins; Liposomes; Oligonucleotides, Antisense/pharmacology; Virus Replication/drug effects; Antiviral Agents/administration & dosage; Base Sequence; Cell Line; HIV-1/drug effects; HIV-1/genetics; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides, Antisense/administration & dosage; RNA, Messenger/metabolism; RNA, Viral/metabolism; Reverse Transcriptase Inhibitors; Ribonuclease H/metabolism; Solutions; T-Lymphocytes/virology; Thionucleotides/chemistry; Thionucleotides/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Virus Replication / Immunotoxins / Oligonucleotides, Antisense / HIV-1 / Liposomes Limits: Humans Language: En Year: 1994 Type: Article

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