Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.

Whyte, M P; Landt, M; Ryan, L M; Mulivor, R A; Henthorn, P S; Fedde, K N; Mahuren, J D; Coburn, S P

Whyte, M P; Landt, M; Ryan, L M; Mulivor, R A; Henthorn, P S; Fedde, K N; Mahuren, J D; Coburn, S P.

Affiliation

Whyte MP; Metabolic Research Unit, Shriners Hospital for Crippled Children, St. Louis, Missouri 63131, USA.

J Clin Invest ; 95(4): 1440-5, 1995 Apr.

Article in En | MEDLINE | ID: mdl-7706447

Subject(s)

Alkaline Phosphatase/metabolism; Hypophosphatasia/enzymology; Isoenzymes/metabolism; Pregnancy/physiology; Diphosphates/metabolism; Ethanolamines/metabolism; Female; Heterozygote; Humans; Hypophosphatasia/genetics; Placenta/enzymology; Prospective Studies; Pyridoxal Phosphate/metabolism; Substrate Specificity

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Full text: 1 Database: MEDLINE Main subject: Pregnancy / Alkaline Phosphatase / Hypophosphatasia / Isoenzymes Type of study: Observational_studies Limits: Female / Humans Language: En Year: 1995 Type: Article

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