Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

Jacobson, N G; Szabo, S J; Weber-Nordt, R M; Zhong, Z; Schreiber, R D; Darnell, J E; Murphy, K M

Jacobson, N G; Szabo, S J; Weber-Nordt, R M; Zhong, Z; Schreiber, R D; Darnell, J E; Murphy, K M.

Affiliation

Jacobson NG; Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

J Exp Med ; 181(5): 1755-62, 1995 May 01.

Article in En | MEDLINE | ID: mdl-7722452

Subject(s)

DNA-Binding Proteins/metabolism; Interleukin-12/pharmacology; Signal Transduction; Th1 Cells/drug effects; Trans-Activators/metabolism; Tyrosine/metabolism; Animals; Base Sequence; Cell Line; DNA/metabolism; Female; Interferon-gamma/biosynthesis; Interferon-gamma/genetics; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; STAT3 Transcription Factor; STAT4 Transcription Factor; Th1 Cells/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Tyrosine / Signal Transduction / Trans-Activators / Th1 Cells / Interleukin-12 / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals Language: En Year: 1995 Type: Article

Fulltext

XML

PubMed Links

Search on Google