Copper chelation-induced reduction of the biological activity of S-nitrosothiols.

Gordge, M P; Meyer, D J; Hothersall, J; Neild, G H; Payne, N N; Noronha-Dutra, A

Gordge, M P; Meyer, D J; Hothersall, J; Neild, G H; Payne, N N; Noronha-Dutra, A.

Affiliation

Gordge MP; Institute of Urology, University College London.

Br J Pharmacol ; 114(5): 1083-9, 1995 Mar.

Article in En | MEDLINE | ID: mdl-7780643

Subject(s)

Blood Platelets/drug effects; Chelating Agents/pharmacology; Copper/physiology; Cysteine/analogs & derivatives; Glutathione/analogs & derivatives; Nitroso Compounds/antagonists & inhibitors; Platelet Aggregation Inhibitors/pharmacology; S-Nitrosothiols; Blood Platelets/metabolism; Copper/blood; Copper/pharmacology; Cyclic GMP/biosynthesis; Cysteine/antagonists & inhibitors; Cysteine/pharmacology; Glutathione/antagonists & inhibitors; Glutathione/pharmacology; Humans; In Vitro Techniques; Iron/blood; Nitroso Compounds/pharmacology; Phenanthrolines/pharmacology; Platelet Aggregation/drug effects; Platelet Count; S-Nitrosoglutathione

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Full text: 1 Database: MEDLINE Main subject: Blood Platelets / Platelet Aggregation Inhibitors / Chelating Agents / Copper / Cysteine / S-Nitrosothiols / Glutathione / Nitroso Compounds Limits: Humans Language: En Year: 1995 Type: Article

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