Effect of methacholine on mucociliary transport in bovine trachea in vitro.

Mars, M H; Henricks, P A; Hajer, R; Breukink, H J

Mars, M H; Henricks, P A; Hajer, R; Breukink, H J.

Affiliation

Mars MH; Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht, The Netherlands.

Am J Vet Res ; 56(4): 486-8, 1995 Apr.

Article in En | MEDLINE | ID: mdl-7785827

ABSTRACT

ABSTRACT

A method is described to evaluate pharmacologic influence on bovine tracheal mucus transport in vitro. In this model, cholinergic agonist methacholine stimulated transport velocity. Methacholine at concentration of 10(-6)M increased velocity by 13.6%, whereas 10(-5)M increased velocity by 26%. Stimulation was inhibited by atropine.

Subject(s)

Cilia/physiology; Methacholine Chloride/pharmacology; Mucus/physiology; Trachea/physiology; Analysis of Variance; Animals; Atropine/pharmacology; Biological Transport/drug effects; Cattle; Cilia/drug effects; In Vitro Techniques; Movement/drug effects; Mucus/drug effects

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PubMed Links

Database: MEDLINE Main subject: Trachea / Methacholine Chloride / Cilia / Mucus Limits: Animals Language: En Year: 1995 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Trachea / Methacholine Chloride / Cilia / Mucus Limits: Animals Language: En Year: 1995 Type: Article