Change of the sequence specificity of daunorubicin-stimulated topoisomerase II DNA cleavage by epimerization of the amino group of the sugar moiety.

Capranico, G; Butelli, E; Zunino, F

Capranico, G; Butelli, E; Zunino, F.

Affiliation

Capranico G; Division of Experimental Oncology B. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Cancer Res ; 55(2): 312-7, 1995 Jan 15.

Article in En | MEDLINE | ID: mdl-7812964

Subject(s)

Antibiotics, Antineoplastic/chemistry; Antibiotics, Antineoplastic/pharmacology; DNA Topoisomerases, Type II/drug effects; DNA/drug effects; Antibiotics, Antineoplastic/metabolism; Base Sequence; DNA/metabolism; DNA Topoisomerases, Type II/chemistry; Daunorubicin/chemistry; Daunorubicin/metabolism; Daunorubicin/pharmacology; Doxorubicin/chemistry; Doxorubicin/metabolism; Doxorubicin/pharmacology; Idarubicin/chemistry; Idarubicin/metabolism; Idarubicin/pharmacology; Molecular Sequence Data; Structure-Activity Relationship

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PubMed Links

Database: MEDLINE Main subject: DNA / DNA Topoisomerases, Type II / Antibiotics, Antineoplastic Language: En Year: 1995 Type: Article

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PubMed Links

Database: MEDLINE Main subject: DNA / DNA Topoisomerases, Type II / Antibiotics, Antineoplastic Language: En Year: 1995 Type: Article