Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-Methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones.

Alpegiani, M; Bissolino, P; Corigli, R; Del Nero, S; Perrone, E; Rizzo, V; Sacchi, N; Cassinelli, G; Franceschi, G; Baici, A

Alpegiani, M; Bissolino, P; Corigli, R; Del Nero, S; Perrone, E; Rizzo, V; Sacchi, N; Cassinelli, G; Franceschi, G; Baici, A.

Affiliation

Alpegiani M; Pharmacia Farmitalia Carlo Erba, R & D, Milano, Italy.

J Med Chem ; 37(23): 4003-19, 1994 Nov 11.

Article in En | MEDLINE | ID: mdl-7966161

Subject(s)

Cephalosporins/pharmacology; Ketones/pharmacology; Pancreatic Elastase/antagonists & inhibitors; Sulfones/pharmacology; Cells, Cultured; Cephalosporins/chemical synthesis; Drug Stability; Elastin/metabolism; Humans; Hydrolysis; Ketones/chemical synthesis; Leukocyte Elastase; Neutrophils/enzymology; Sulfones/chemical synthesis

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Database: MEDLINE Main subject: Sulfones / Pancreatic Elastase / Cephalosporins / Ketones Limits: Humans Language: En Year: 1994 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Sulfones / Pancreatic Elastase / Cephalosporins / Ketones Limits: Humans Language: En Year: 1994 Type: Article