A familial/genetic study of plasma serine and glycine concentrations.

Devor, E J; Waziri, R

Devor, E J; Waziri, R.

Affiliation

Devor EJ; Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.

Biol Psychiatry ; 34(4): 221-5, 1993 Aug 15.

Article in En | MEDLINE | ID: mdl-8399818

ABSTRACT

ABSTRACT

Plasma serine and glycine concentrations were assayed in a sample of 28 nuclear families (n = 108). Complex segregation analysis of these familial data reveals significant genetic control of concentrations via a single major gene locus. The serine and glycine metabolizing enzyme serine hydroxymethyltransferase (SHMT) is suggested as the most likely candidate for this single major gene locus.

Subject(s)

Glycine/blood; Psychotic Disorders/genetics; Schizophrenia/blood; Serine/blood; Dopamine/metabolism; Female; Glucose/metabolism; Glutamates/genetics; Glutamates/metabolism; Glutamates/physiology; Glycine/genetics; Humans; Internal-External Control; Male; Mitochondria/metabolism; Psychotic Disorders/blood; Schizophrenia/genetics; gamma-Aminobutyric Acid/metabolism

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Psychotic Disorders / Schizophrenia / Serine / Glycine Limits: Female / Humans / Male Language: En Year: 1993 Type: Article

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Psychotic Disorders / Schizophrenia / Serine / Glycine Limits: Female / Humans / Male Language: En Year: 1993 Type: Article