Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.

Pellicciari, R; Marinozzi, M; Natalini, B; Costantino, G; Luneia, R; Giorgi, G; Moroni, F; Thomsen, C

Pellicciari, R; Marinozzi, M; Natalini, B; Costantino, G; Luneia, R; Giorgi, G; Moroni, F; Thomsen, C.

Affiliation

Pellicciari R; Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.

J Med Chem ; 39(11): 2259-69, 1996 May 24.

Article in En | MEDLINE | ID: mdl-8667369

Subject(s)

Cyclopropanes/chemical synthesis; Cyclopropanes/pharmacology; Glycine/analogs & derivatives; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Alternative Splicing; Animals; Cell Membrane/metabolism; Cerebral Cortex/metabolism; Cricetinae; Crystallography, X-Ray; Cyclopropanes/chemistry; Genetic Variation; Glycine/chemical synthesis; Glycine/chemistry; Glycine/pharmacology; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Piperazines/metabolism; Rats; Receptors, Metabotropic Glutamate/biosynthesis; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/biosynthesis; Stereoisomerism; Structure-Activity Relationship; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism

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Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Cyclopropanes / Glycine Limits: Animals Language: En Year: 1996 Type: Article

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Cyclopropanes / Glycine Limits: Animals Language: En Year: 1996 Type: Article