Internalization and biological effects of serum albumin in the breast cancer MCF-7 and MDA-MB 231 cells.
Cell Mol Biol (Noisy-le-grand)
; 41(8): 1119-29, 1995 Dec.
Article
in En
| MEDLINE
| ID: mdl-8747093
ABSTRACT
We show that albumin is internalized by human breast cancer cells (MDA-MB 231 and MCF-7) in culture by using confocal laser scanning microscopy. Moreover, albumin has an effect on the level of radioactivity incorporated when the cells are incubated with radioactive estradiol, and it is necessary to observe the mitogenic effect of estradiol towards the MCF-7 cells. This finding opens some possibilities regarding the internalization mechanisms and fate (degradation, recycling) of albumin as well as the role played by this protein in the intracellular metabolism of estradiol and in the intra-extracellular traffic of estradiol and its metabolites.
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Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Serum Albumin, Bovine
Limits:
Female
/
Humans
Language:
En
Year:
1995
Type:
Article