Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

Mercken, M; Takahashi, H; Honda, T; Sato, K; Murayama, M; Nakazato, Y; Noguchi, K; Imahori, K; Takashima, A

Mercken, M; Takahashi, H; Honda, T; Sato, K; Murayama, M; Nakazato, Y; Noguchi, K; Imahori, K; Takashima, A.

Affiliation

Mercken M; Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.

FEBS Lett ; 389(3): 297-303, 1996 Jul 08.

Article in En | MEDLINE | ID: mdl-8766720

Subject(s)

Alzheimer Disease/metabolism; Membrane Proteins/chemistry; Protein Processing, Post-Translational; Alzheimer Disease/genetics; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Brain/metabolism; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epitopes; Escherichia coli/genetics; Glutathione Transferase/genetics; Glutathione Transferase/metabolism; Humans; Membrane Proteins/genetics; Membrane Proteins/immunology; Membrane Proteins/isolation & purification; Membrane Proteins/metabolism; Molecular Sequence Data; Molecular Weight; Mutation; PC12 Cells; Peptide Fragments/chemistry; Peptide Fragments/immunology; Presenilin-1; Rats; Recombinant Fusion Proteins/metabolism; Transfection

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Database: MEDLINE Main subject: Protein Processing, Post-Translational / Alzheimer Disease / Membrane Proteins Limits: Animals / Humans Language: En Year: 1996 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Protein Processing, Post-Translational / Alzheimer Disease / Membrane Proteins Limits: Animals / Humans Language: En Year: 1996 Type: Article