Corticosteroid treatment of experimental autoimmune encephalomyelitis in the Lewis rat results in loss of V beta 8.2+ and myelin basic protein-reactive cells from the spinal cord, with increased total T-cell apoptosis but reduced apoptosis of V beta 8.2+ cells.

McCombe, P A; Nickson, I; Tabi, Z; Pender, M P

McCombe, P A; Nickson, I; Tabi, Z; Pender, M P.

Affiliation

McCombe PA; Department of Medicine, University of Queensland, Royal Brisbane Hospital, Herston, Australia.

J Neuroimmunol ; 70(2): 93-101, 1996 Nov.

Article in En | MEDLINE | ID: mdl-8898717

Subject(s)

Apoptosis/drug effects; Dexamethasone/pharmacology; Encephalomyelitis, Autoimmune, Experimental/drug therapy; Glucocorticoids/pharmacology; Receptors, Antigen, T-Cell, alpha-beta/genetics; T-Lymphocyte Subsets/drug effects; Animals; Encephalomyelitis, Autoimmune, Experimental/pathology; Female; Male; Myelin Basic Protein/immunology; Rats; Rats, Inbred Lew; Spinal Cord/pathology; T-Lymphocyte Subsets/cytology

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Database: MEDLINE Main subject: Dexamethasone / T-Lymphocyte Subsets / Receptors, Antigen, T-Cell, alpha-beta / Apoptosis / Encephalomyelitis, Autoimmune, Experimental / Glucocorticoids Limits: Animals Language: En Year: 1996 Type: Article

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