Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. I. Taxonomy of producing organism, fermentation and biological activity.
J Antibiot (Tokyo)
; 49(9): 860-4, 1996 Sep.
Article
in En
| MEDLINE
| ID: mdl-8931718
ABSTRACT
Strain C39217-R109-7 (ATCC 53791) is an actinomycete strain isolated from a soil sample collected at Puerto Viejo, Peru. It produces a new antitumor antibiotic, designated pyrrolosporin A. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Micromonospora sp. C39217-R109-7. Pyrrolosporin A shows antimicrobial activity against Gram-positive bacteria and it is weakly active against Gram-negative bacteria. Pyrrolosporin A prolongs the life span of mice inoculated with P388 leukemia cells.
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Database:
MEDLINE
Main subject:
Macrolides
/
Fermentation
/
Micromonospora
/
Anti-Bacterial Agents
/
Antibiotics, Antineoplastic
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Year:
1996
Type:
Article