Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.

Medina, V; Edmonds, B; Young, G P; James, R; Appleton, S; Zalewski, P D

Medina, V; Edmonds, B; Young, G P; James, R; Appleton, S; Zalewski, P D.

Affiliation

Medina V; Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia.

Cancer Res ; 57(17): 3697-707, 1997 Sep 01.

Article in En | MEDLINE | ID: mdl-9288776

Subject(s)

Apoptosis; Butyrates/pharmacology; Caspases; Cysteine Endopeptidases/metabolism; Histone Deacetylases/pharmacology; Hydroxamic Acids/pharmacology; Apoptosis/genetics; Butyric Acid; Caspase 3; Cells, Cultured; Cycloheximide/pharmacology; Cytochrome c Group/metabolism; DNA Fragmentation; DNA, Neoplasm/drug effects; Enzyme Induction; Humans; Jurkat Cells/drug effects; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Synthesis Inhibitors/pharmacology; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Staurosporine/metabolism; bcl-2-Associated X Protein

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Database: MEDLINE Main subject: Butyrates / Cysteine Endopeptidases / Apoptosis / Caspases / Histone Deacetylases / Hydroxamic Acids Limits: Humans Language: En Year: 1997 Type: Article

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