Arteritis and increased intracellular calcium as a possible mechanism for tacrolimus-related cardiac toxicity in a pediatric transplant recipient.
Transplantation
; 64(5): 773-5, 1997 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-9311719
ABSTRACT
We recently reported partially to wholly reversible hypertrophic cardiomyopathy, including severe hypertrophic obstructive cardiomyopathy, as a side effect in pediatric transplant recipients receiving tacrolimus immunosuppression. This seemed to be dose related. We describe a pediatric patient receiving tacrolimus who died 3 weeks after liver/bowel transplantation. Postmortem findings revealed arteritis of cardiac arteries and extensive calcification of cardiac tissue suggesting a possible mechanism of tacrolimus cardiac toxicity. This is consistent with recent reports of tacrolimus increasing calcium release into the sarcoplasmic reticulum of cardiac and striated muscle.
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Database:
MEDLINE
Main subject:
Arteritis
/
Cardiomyopathy, Hypertrophic
/
Calcium
/
Liver Transplantation
/
Tacrolimus
/
Immunosuppressive Agents
/
Intestine, Small
Limits:
Child, preschool
/
Humans
/
Male
Language:
En
Year:
1997
Type:
Article