Tumor differentiation-dependent local immunity in human head and neck cancers.
Cancer Lett
; 123(2): 173-6, 1998 Jan 30.
Article
in En
| MEDLINE
| ID: mdl-9489485
ABSTRACT
Distribution of markers of local cell-mediated immunity was examined in oral tumors exhibiting different histological stages of differentiation. Using a RT-PCR-based semiquantitative technique we determined levels of Langerhans cells, CD4- and CD8-positive T-cells, macrophages/NK cells, beta2-microglobulin and IFN-gamma mRNAs from tissue biopsies. A positive correlation was found between levels of these immunological markers and the tumor differentiation stage. Since tumor differentiation may correlate with the prognosis and response to various treatment modalities, our results may be useful clinically.
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Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Head and Neck Neoplasms
Limits:
Humans
Language:
En
Year:
1998
Type:
Article