MK-801 does not enhance dopaminergic cell survival in embryonic nigral grafts.
Neuroreport
; 9(7): 1313-6, 1998 May 11.
Article
in En
| MEDLINE
| ID: mdl-9631420
ABSTRACT
Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase positive neurones in the grafts. These findings suggest that cell death occurring during nigral transplantation is not primarily due to excitotoxicity.
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Database:
MEDLINE
Main subject:
Parkinson Disease, Secondary
/
Mesencephalon
/
Brain Tissue Transplantation
/
Dizocilpine Maleate
/
Fetal Tissue Transplantation
/
Graft Survival
/
Neurons
Limits:
Animals
Language:
En
Year:
1998
Type:
Article