Brain infarction following 5-fluorouracil and cisplatin therapy.
Neurology
; 51(3): 899-901, 1998 Sep.
Article
in En
| MEDLINE
| ID: mdl-9748055
ABSTRACT
Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients. There may be a relation between treatment and brain infarction because 1) there was no other cause identified despite extensive tests, including postmortem examination in one patient; 2) there was a short delay between treatment infusion and stroke; and 3) there was a similar pattern of ischemic stroke after the second or third course of chemotherapy.
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Database:
MEDLINE
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Cerebral Infarction
/
Cisplatin
/
Fluorouracil
Type of study:
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
1998
Type:
Article