Carbamoyl phosphate synthetase: a tunnel runs through it.
Curr Opin Struct Biol
; 8(6): 679-85, 1998 Dec.
Article
in En
| MEDLINE
| ID: mdl-9914247
ABSTRACT
The direct transfer of metabolites from one protein to another in a biochemical pathway or between one active site and another within a single enzyme has been described as substrate channeling. The first structural visualization of such a phenomenon was provided by the X-ray crystallographic analysis of tryptophan synthase, in which a tunnel of approximately 25 A in length was observed. The recently determined three-dimensional structure of carbamoyl phosphate synthetase sets a new long distance record in that the three active sites are separated by nearly 100 A.
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Database:
MEDLINE
Main subject:
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Language:
En
Year:
1998
Type:
Article