[Effect of antibiotics and antibody on phagocytic bactericidal activity of polymorphonuclear neutrophils of Bordetella pertussis].
Kansenshogaku Zasshi
; 73(3): 239-43, 1999 Mar.
Article
en Ja
| MEDLINE
| ID: mdl-10222670
ABSTRACT
The phagocytic bactericidal activity of the polymononucler neutrophils (PMNs) that were collected from healthy volunteer with and without antibody against Bordetella pertussis was investigated. Furthermore, these activity against B. pertussis under observing penicillins or macrolides antibiotics was investigated. Although no efficacy to B. pertussis strain by the PMNs in serum without antibody, but the viable cells of B. pertussis decreased to 1/1,000 1 hr after incubation and was not detected after 4 hrs. In particular, the viable cells of B. pertussis by the PMNs in serum with antibody was markedly reduced when azithromycin was present. These results suggests that the synergistic action of macrolide antibiotics and antibody-mediated phagocytic bactericidal activity on B. pertussis may have clinical relevance.
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Banco de datos:
MEDLINE
Asunto principal:
Penicilinas
/
Fagocitosis
/
Bordetella pertussis
/
Antibacterianos
/
Anticuerpos Antibacterianos
Límite:
Humans
Idioma:
Ja
Año:
1999
Tipo del documento:
Article