[Electron microscope study of lung carcinoid]. / Elektronno-mikroskopicheskoe issledovanie kartsinoidov legkogo.

ABSTRACT

123 lung carcinoids were studied, 32 of them electron-microscopically. Ultrastructural features were evaluated with the use of multivariate analysis. The most informative ultrastructural features were the following correlation between differentiated and undifferentiated cells, the number of cytoplasm organoids including endocrine granules, degree of nuclei polymorphism and their size, specialized contacts, mitoses. Up to 18% of carcinoids, on the average, need ultrastructural verification of the anaplasia degree, this percentage increasing to 27.2% in atypical carcinoids. The above ultrastructural criteria allow to specify malignant potential of carcinoids, facilitate differential diagnosis and make their prognosis.