The role of phosphatidylinositide-3-kinase in basal mitogen-activated protein kinase activity and cell survival.
FEBS Lett
; 465(1): 69-73, 2000 Jan 07.
Article
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| MEDLINE
| ID: mdl-10620708
ABSTRACT
Phosphatidylinositide-3-OH-kinase (PI 3-kinase) is an upstream activator of p42/p44 mitogen-activated protein kinase (MAPK), but the role of PI 3-kinase-dependent MAPK remains obscure. Here we demonstrate that in a variety of different cell types, PI 3-kinase inhibition results in an inhibition of MAPK in unstimulated cells but does not interfere with growth factor-, or TPA-induced MAPK activity. Furthermore, inhibition of either PI 3-kinase or MEK/MAPK results in cell death in serum-starved cells. We concluded that basal, but not induced MAPK activity is mediated by PI 3-kinase and that this PI 3-kinase-mediated MEK/MAPK activity is essential for cell survival in quiescent cells.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas Serina-Treonina Quinasas
/
Fosfatidilinositol 3-Quinasas
/
Quinasas de Proteína Quinasa Activadas por Mitógenos
Límite:
Animals
Idioma:
En
Año:
2000
Tipo del documento:
Article