Enhanced apoptosis in retrovirally transfected osteosarcoma cells after exposure to sodium butyrate.
Int J Oncol
; 16(4): 695-700, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10717237
ABSTRACT
We investigated the effects of sodium butyrate (NaBu) on two retrovirally transfected osteosarcoma cell lines (1547-TK and 1547-LacZ cells) compared to the corresponding untransfected cell line. The first finding was an inhibitory effect only on the proliferation of both transfected cell lines. This antiproliferative effect was associated with apoptosis induction, which was detected using techniques that monitor either characteristic biochemical or morphological processes. Our findings show that 1547-TK and 1547-LacZ cells were much more sensitive to NaBu treatment than untransfected 1547 cells as concerns both proliferation and apoptosis induction.
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Banco de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Neoplasias Óseas
/
Butiratos
/
Osteosarcoma
/
Apoptosis
Límite:
Humans
Idioma:
En
Año:
2000
Tipo del documento:
Article