High-performance liquid chromatographic analysis of penicillin V benzathine oral suspensions.
J Pharm Sci
; 68(5): 555-6, 1979 May.
Article
en En
| MEDLINE
| ID: mdl-107312
ABSTRACT
A rapid high-performance liquid chromatographic assay for penicillin V content of penicillin V benzathine bulk drug and oral suspensions is described. Dilution of the oral suspension with methanol containing 1,3,5-trimethoxybenzene as the internal standard allowed for direct analysis on a reversed-phase column with a mobile phase of 53% methanol in 0.05 M aqueous pH 3.5 phosphate buffer. A relative standard deviation of less than 1% was obtained on commercial formulations, and the system was linear over a range 10-40 microgram injected.
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Banco de datos:
MEDLINE
Asunto principal:
Penicilina V
Idioma:
En
Año:
1979
Tipo del documento:
Article