Mismatch repair proteins and mitotic genome stability.
Mutat Res
; 451(1-2): 151-67, 2000 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-10915870
ABSTRACT
Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their absence, mutations accumulate at elevated rates. In addition, MMR proteins inhibit recombination between non-identical DNA sequences, and hence prevent genome rearrangements resulting from interactions between repetitive elements. This review provides an overview of the anti-mutator and anti-recombination functions of MMR proteins in the yeast Saccharomyces cerevisiae.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas
/
Técnicas Genéticas
/
Adenosina Trifosfatasas
/
Proteínas de Escherichia coli
/
Proteínas de Unión al ADN
/
Reparación del ADN
/
Mitosis
Límite:
Humans
Idioma:
En
Año:
2000
Tipo del documento:
Article