Structural and functional features of eukaryotic mRNA untranslated regions.

Pesole, G; Mignone, F; Gissi, C; Grillo, G; Licciulli, F; Liuni, S

Pesole, G; Mignone, F; Gissi, C; Grillo, G; Licciulli, F; Liuni, S.

Afiliación

Pesole G; Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria, 26, 20133, Milan, Italy. graziano.pesole@unimi.it

Gene ; 276(1-2): 73-81, 2001 Oct 03.

Article en En | MEDLINE | ID: mdl-11591473

ABSTRACT

ABSTRACT

The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization.

Asunto(s)

Regiones no Traducidas 3'/genética; Regiones no Traducidas 5'/genética; Células Eucariotas/metabolismo; ARN Mensajero/genética; Animales; Composición de Base; Secuencia de Bases; Secuencia Conservada; Bases de Datos Factuales; Humanos; Intrones; Secuencias Reguladoras de Ácidos Nucleicos; Secuencias Repetitivas de Ácidos Nucleicos

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Banco de datos: MEDLINE Asunto principal: ARN Mensajero / Regiones no Traducidas 3' / Regiones no Traducidas 5' / Células Eucariotas Límite: Animals / Humans Idioma: En Año: 2001 Tipo del documento: Article

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