Arthritis following recombinant outer surface protein A vaccination for Lyme disease.
J Rheumatol
; 28(11): 2555-7, 2001 Nov.
Article
en En
| MEDLINE
| ID: mdl-11708435
ABSTRACT
As more individuals receive outer surface protein A (OspA) vaccination, adverse effects not detected during phase III clinical trials may become apparent. Although arthritis has been described following other human vaccines, we found no reports of human cases after Lyme disease vaccination. We describe 4 males (2 children, 2 adults) who developed arthritis following recombinant OspA vaccination. The potential arthritogenic effect of OspA suggested by in vitro and animal studies finds a clinical correlate in these 4 cases.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas de la Membrana Bacteriana Externa
/
Enfermedad de Lyme
/
Artritis Reactiva
/
Vacunas contra Enfermedad de Lyme
/
Lipoproteínas
/
Antígenos de Superficie
Límite:
Adolescent
/
Adult
/
Child
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2001
Tipo del documento:
Article