Copper amine oxidase: cunning cofactor and controversial copper.
Curr Opin Struct Biol
; 11(6): 666-73, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11751046
ABSTRACT
Copper amine oxidases have a complex reaction cycle that converts a primary amine and molecular oxygen into the aldehyde, ammonia and hydrogen peroxide. Coupling structural studies of freeze-trapped reaction intermediates in crystals with kinetic and spectroscopic experiments in solution has generated a detailed molecular picture of catalysis. Although dioxygen has been directly observed bound to the copper at a late stage in the reaction cycle, whether copper is the initial binding site remains controversial.
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Banco de datos:
MEDLINE
Asunto principal:
Dihidroxifenilalanina
/
Amina Oxidasa (conteniendo Cobre)
Límite:
Animals
Idioma:
En
Año:
2001
Tipo del documento:
Article