Cytokine production in patients with tuberculous pericarditis.
Int J Tuberc Lung Dis
; 6(5): 439-46, 2002 May.
Article
en En
| MEDLINE
| ID: mdl-12019920
ABSTRACT
SETTING:
An academic hospital in the Western Cape, South Africa.OBJECTIVE:
To evaluate cytokine production (interferon-gamma [IFN-gamma], interleukin-1 [IL-1], interleukin-2 [IL-2], interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-4 [IL-4] and tumour necrosis factor-alpha [TNF-alpha]) in patients with tuberculous pericarditis.DESIGN:
Subpopulation of a consecutive prospective case series. PATIENTS Thirty patients presenting with pericardial effusions due to tuberculosis (n = 19), malignancy (n = 6) and non-tuberculous infections (n = 5), and five control subjects who had undergone open heart surgery.RESULTS:
The concentration of IFN-gamma was significantly higher in tuberculous pericardial effusions than in the other diagnostic classes (P < 0.0005). The concentration of TNF-alpha was similar in both infective and tuberculous effusions, but was significantly higher than that of malignant effusions. IL-1 and IL-2 were undetectable in malignant effusions, but elevated in both infective and tuberculous pericardial effusions. The levels of IL-1 and IL-2 were furthermore significantly higher in pericardial effusions due to infective compared to tuberculous causes. The concentration of IL-6, while elevated in all diagnostic classes, was significantly higher in the malignant group. Elevated levels of IL-10 and undetectable levels of IL-4 were observed in all three diagnostic groups.CONCLUSION:
These findings suggest that tuberculous pericardial effusions arise due to a hypersensitivity reaction that is orchestrated by the TH-1 lymphocytes.
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Banco de datos:
MEDLINE
Asunto principal:
Pericarditis Tuberculosa
/
Citocinas
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Interleucina-4
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Interleucina-6
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Interferón gamma
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Interleucina-1
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Interleucina-2
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Factor de Necrosis Tumoral alfa
/
Interleucina-10
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2002
Tipo del documento:
Article