Temporal pole MRI abnormalities in temporal lobe epilepsy.
Epileptic Disord
; 4 Suppl 1: S33-9, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12424089
ABSTRACT
Magnetic resonance imaging (MRI) demonstrates an abnormal aspect of the temporo-polar region in 1/3 to 2/3 of patients suffering from cryptogenic temporal lobe epilepsy. This abnormal aspect is described as a white matter increased T2 signal, resulting in a loss of gray-white matter demarcation, often associated with atrophy, as recently confirmed by quantitative volumetric measurements. These temporo-polar MRI findings appear to correctly lateralize the epileptogenic temporal lobe with a very high specificity, and have never been reported in extra-temporal lobe epilepsy nor in control subjects. They are usually associated with MRI signs of hippocampal sclerosis, but the two conditions seem to be partly distinct from a pathophysiological point of view. Pathological correlates of temporo-polar white matter increased T2 signal are controversial, but the role of an abnormal myelin seems more likely than that of ectopic neurons. A myelin dysfunction would also be consistent with the correlation observed between lateral temporal hypometabolism and temporo-polar MRI abnormalities. Whether or not these MRI findings are associated with a better seizure outcome following temporal lobectomy remains a debated issue.
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Banco de datos:
MEDLINE
Asunto principal:
Lóbulo Temporal
/
Imagen por Resonancia Magnética
/
Epilepsia del Lóbulo Temporal
Límite:
Humans
Idioma:
En
Año:
2002
Tipo del documento:
Article