Acremonium strictum pulmonary infection in a leukemic patient successfully treated with posaconazole after failure of amphotericin B.
Eur J Clin Microbiol Infect Dis
; 21(11): 814-7, 2002 Nov.
Article
en En
| MEDLINE
| ID: mdl-12461592
ABSTRACT
A severely neutropenic patient with chronic lymphocytic leukemia developed a diffuse bilateral pulmonary infection while receiving a therapeutic daily dosage of intravenous amphotericin B for Candida glabrata esophagitis. Computed tomography of the chest showed numerous lung nodules, ground glass areas and a pleural effusion. Biopsy of one nodule demonstrated hyaline septate hyphae. Multiple sputum cultures grew Acremonium strictum. Increasing the dose of amphotericin B and the addition of itraconazole did not resolve the infection. Change of treatment to posaconazole given orally at 200 mg four times/d resulted in progressive improvement leading finally to cure after 24 weeks of therapy. Treatment with posaconazole was clinically and biologically well tolerated.
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Banco de datos:
MEDLINE
Asunto principal:
Triazoles
/
Acremonium
/
Anfotericina B
/
Huésped Inmunocomprometido
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Enfermedades Pulmonares Fúngicas
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
2002
Tipo del documento:
Article