Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.
Anticancer Res
; 22(6B): 3727-31, 2002.
Article
en En
| MEDLINE
| ID: mdl-12552984
ABSTRACT
This study assessed the efficacy of combined prophylactic and curative anti-diarrhoeal medication in advanced colorectal patients treated by irinotecan. Thirty-four pre-treated eligible patients were evaluated. There were 44% women, the median age was 65 and 38% of the patients had a 0 performance status. The patients received sucralfate(4g/d) and nifuroxazide(600 mg/d) prophylactic treatment on days 0-7. In the case of severe diarrhoea, preventive treatment was replaced by loperamide(12 mg/d) and diosmectite (9 g/d). Grade 3 delayed diarrhoea occurred in 18% of patients (90% CI [9.5-28.9]) and 4.6% of cycles. No grade 4 delayed diarrhoea was observed. Twenty-nine patients (85%) received the preventive treatment at cycle 1, while 14% (90% CI [6.2-25.7]) experienced grade 3 delayed diarrhoea in 3.7% of cycles for a median 4.5 days. The objective response rate was 8% (90% CI [1.4-23.1]) among the 25 assessable patients. Preventive combined treatment is effective in reducing the incidence of severe delayed diarrhoea, and it should be proposed to patients treated with mono-therapy Campto(r) and evaluated in poly-chemotherapy protocols.
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Banco de datos:
MEDLINE
Asunto principal:
Sucralfato
/
Camptotecina
/
Neoplasias Colorrectales
/
Adenocarcinoma
/
Silicatos
/
Diarrea
/
Hidroxibenzoatos
/
Antidiarreicos
/
Antineoplásicos Fitogénicos
/
Nitrofuranos
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Año:
2002
Tipo del documento:
Article