Recurrent, isolated factor X deficiency in myeloma: repeated normalization of factor X levels after cytostatic chemotherapy followed by late treatment failure associated with the development of systemic amyloidosis.
Thromb Haemost
; 68(6): 648-51, 1992 Dec 07.
Article
en En
| MEDLINE
| ID: mdl-1287879
ABSTRACT
We describe the case of a 64-year-old woman with isolated severe factor X deficiency associated with kappa light chain myeloma. At the time of diagnosis there was no evidence for amyloidosis. Complete remission (CR) of myeloma as well as normalization of factor X levels were achieved after cytostatic chemotherapy. Subsequently, factor X deficiency recurred twice without any evidence for relapse of myeloma. The first time factor X normalized again following cytostatic treatment, the second time, however, factor X deficiency was refractory to chemotherapy. Finally, relapse of myeloma became evident associated with rapidly progressing, systemic amyloidosis, which was fatal within a few months. Initially, factor X infusion studies showed a normal recovery, but when amyloidosis became overt the recovery decreased to 0%. We assume that factor X deficiency was due to a binding of factor X to kappa light chains associated with the proliferation of the malignant myeloma cell clone.
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Banco de datos:
MEDLINE
Asunto principal:
Factor X
/
Deficiencia del Factor X
/
Amiloidosis
/
Mieloma Múltiple
/
Antineoplásicos
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
1992
Tipo del documento:
Article