HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy.
J Clin Invest
; 112(6): 824-6, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-12975465
ABSTRACT
Histone acetylation, regulated by two antagonistic enzymes - histone acetyltransferases (HATs) and histone deacetylases (HDACs) - results in transcriptional changes and also plays a critical role in cardiac development and disease. A new study shows that overexpression of the atypical transcriptional corepressor homeodomain-only protein (Hop) causes cardiac hypertrophy via recruitment of a class I HDAC. In contrast to the body of work on transcriptional mechanisms that drive cardiac hypertrophy, including class II HDACs, this report elucidates a novel growth-suppressing transcriptional pathway in cardiac muscle that opposes hypertrophic growth.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
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Acetiltransferasas
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Transcripción Genética
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Cardiomegalia
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Proteínas de Saccharomyces cerevisiae
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Histona Desacetilasas
Límite:
Animals
Idioma:
En
Año:
2003
Tipo del documento:
Article