Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism.
FEBS Lett
; 305(3): 254-6, 1992 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-1299626
ABSTRACT
Apocynin is a constituent of root extracts of the medicinal herb Picrorhiza kurroa and has been shown to possess anti-inflammatory properties. We investigated the effects of apocynin on the production of arachidonic acid-derived inflammatory mediators by guinea pig pulmonary macrophages. Apocynin concentration-dependently inhibited the formation of thromboxane A2, whereas the release of prostaglandins E2 and F2 alpha was stimulated. Apocynin potently inhibited arachidonic acid-induced aggregation of bovine platelets, possibly through inhibition of thromboxane formation. The present results suggest that apocynin might, beside its therapeutic effects in inflammatory conditions when given in a root extract of P. kurroa, also be a valuable tool in the development of new anti-inflammatory or anti-thrombic drugs.
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Banco de datos:
MEDLINE
Asunto principal:
Acetofenonas
/
Extractos Vegetales
/
Antiinflamatorios no Esteroideos
/
Ácido Araquidónico
Límite:
Animals
Idioma:
En
Año:
1992
Tipo del documento:
Article