Human T lymphotropic virus type 1 in a seronegative B chronic lymphocytic leukemia patient.
Med Microbiol Immunol
; 192(4): 205-9, 2003 Nov.
Article
en En
| MEDLINE
| ID: mdl-14615889
ABSTRACT
Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 infection in patients with B cell-type chronic lymphocytic leukemia (B-CLL) is rare and has been reported only in areas in which HTLV-1 is endemic. In the present study, we detected HTLV-1 proviral DNA by polymerase chain reaction, using tax primers, in peripheral blood lymphocytes from a B-CLL patient, an immigrant to Israel, where HTLV-1 infection is not endemic. F344 rats injected intravenously with peripheral blood lymphocytes obtained from the patient developed HTLV-1 antibodies. Titers of antibody to HTLV-1 in the rat blood were 1512 by particle agglutination; enzyme-linked immunosorbent assay and Western blotting were also positive. No antibody against HTLV-1 was demonstrated in the animal model after inoculation of either purified B lymphocytes from the B-CLL patient or peripheral blood mononuclear cells from healthy donors. This is one of the few studies showing the presence of HTLV-1 provirus in T lymphocytes of a B-CLL patient who had multiple infections, and died of salmonella sepsis, and the first report of HTLV-1 antibody induction in an animal model by inoculation of lymphocytes obtained from an HTLV-1-infected B-CLL patient.
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Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Virus Linfotrópico T Tipo 1 Humano
/
Infecciones por HTLV-I
/
Leucemia Linfocítica Crónica de Células B
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Animals
/
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Año:
2003
Tipo del documento:
Article