Tumbling down a different pathway to genetic instability.
J Clin Invest
; 112(12): 1793-5, 2003 Dec.
Article
en En
| MEDLINE
| ID: mdl-14679175
ABSTRACT
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Colitis Ulcerosa
/
Repeticiones de Microsatélite
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Article