Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.
Cancer Cell
; 6(3): 251-61, 2004 Sep.
Article
en En
| MEDLINE
| ID: mdl-15380516
ABSTRACT
Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.
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Banco de datos:
MEDLINE
Asunto principal:
Activación Transcripcional
/
Prostaglandina-Endoperóxido Sintasas
/
Receptor ErbB-2
/
Isoenzimas
Límite:
Humans
Idioma:
En
Año:
2004
Tipo del documento:
Article