The pp67 mRNA assay in treatment and monitoring of cytomegalovirus disease in renal transplant patients in India.
Transpl Infect Dis
; 6(2): 90-2, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15522113
ABSTRACT
The present report describes use of nucleic acid sequence-based amplification (NASBA) technology to detect pp67 mRNA of cytomegalovirus (CMV) in transplant patients in India. In our experience, pp67 mRNA assay was an accurate, rapid, and effective diagnostic tool to detect active CMV disease in 40.7% (50/123) of symptomatic transplant cases. This assay also allowed us to monitor CMV therapy. As part of the immunosuppressive regimen mycophenolate mofetil was found to increase the risk of developing CMV disease. All positive cases with this assay were subjected to antiviral therapy, with complete remission of the disease. At our center CMV NASBA assay has become the gold standard for the diagnosis of CMV disease in transplant patients.
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Banco de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
ARN Mensajero
/
Proteínas de la Matriz Viral
/
Trasplante de Riñón
/
Infecciones por Citomegalovirus
/
Replicación de Secuencia Autosostenida
/
Citomegalovirus
/
Ácido Micofenólico
Tipo de estudio:
Etiology_studies
/
Evaluation_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Año:
2004
Tipo del documento:
Article