No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
Am J Hum Genet
; 76(3): 517-21, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15660293
ABSTRACT
Attempts to identify susceptibility loci that, on their own, have marginal main effects by use of gene-gene interaction tests have increased in popularity. The results obtained from analyses of epistasis are, however, difficult to interpret. Gene-gene interaction, albeit only marginally significant, has recently been reported for the interleukin-4 and interleukin-13 genes (IL4 and IL13) with the interleukin-4 receptor A gene (IL4RA), contributing to the susceptibility of type 1 diabetes (T1D). We aimed to replicate these findings by genotyping both large family and case-control data sets and by using previously published data. Gene-gene interaction tests were performed using linear regression models in cases only. We did not find any single-locus associations with T1D and did not obtain evidence of gene-gene interaction. Additional support from independent samples will be even more important in the study of gene-gene interactions and other subgroup analyses.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transactivadores
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Interleucina-4
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Interleucina-13
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Diabetes Mellitus Tipo 1
/
Proteínas de Unión al ADN
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Año:
2005
Tipo del documento:
Article