The cytokine gene polymorphisms in patients with chronic kidney graft rejection.
Transpl Immunol
; 14(1): 49-52, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15814282
ABSTRACT
Chronic allograft rejection remains an important cause of morbidity after kidney transplantation. The aim of the study was to examine the association between IL-2, IL-6 and TNF-alpha promoter polymorphisms and chronic kidney allograft rejection. The study included 64 patients with long-term stable graft function and 62 with chronic allograft nephropathy. Among patients with chronic allograft nephropathy a statistically significant prevalence of the IL-6 CC genotype associated with low IL-6 expression was observed (p < 0.01, OR 3.18; 95% CI 1.27-8.15). There were no statistically significant differences in distribution of IL-2 and TNF-alpha genotypes between patients with stable graft function and chronic allograft rejection. The results of present study suggest that the genetically determined low IL-6 production may be the risk factor of chronic allograft nephropathy development.
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Banco de datos:
MEDLINE
Asunto principal:
Citocinas
/
Trasplante de Riñón
/
Rechazo de Injerto
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article