Genetic and environmental contributions to serum retinol and alpha-tocopherol concentrations: the Stanislas Family Study.
Am J Clin Nutr
; 81(5): 1034-44, 2005 May.
Article
en En
| MEDLINE
| ID: mdl-15883426
ABSTRACT
BACKGROUND:
Although numerous environmental factors are documented to influence serum retinol and alpha-tocopherol concentrations, little is known about the genetic versus the environmental contributions to variations in these traits.OBJECTIVE:
The aim of this study was to estimate additive genetic heritability and household effects for serum retinol and alpha-tocopherol concentrations in a variance component analysis.DESIGN:
In a sample of 387 French families, information on serum retinol and alpha-tocopherol concentrations, usual dietary intake, lifestyle, and serum lipid profiles and related polymorphisms (apolipoprotein E, apolipoprotein C-III, apolipoprotein B, cholesteryl ester transfer protein, and lipoprotein lipase) was obtained.RESULTS:
For serum retinol--after adjustment for sex, age, body mass index, alcohol consumption, oral contraceptive use, and serum albumin, triacylglycerol, and apolipoprotein A-I concentrations--additive genetic effects and shared common environment contributed 30.5% and 14.2% of the total variance, respectively. For serum alpha-tocopherol, approximately 22.1% of the total variance was due to the additive effects of genes and 18.7% to those of household environment, after adjustment for the covariates sex, age, vitamin E intake, oral contraceptive use, and cholesterol, triacylglycerol, and apolipoprotein A-I concentrations. For both vitamins, the influence of measured polymorphisms was not significant. Moreover, heritability and household effect estimates were not significantly different between the 4 classes of relatives and did not vary significantly when families shared more meals at home.CONCLUSIONS:
The results show that serum retinol and alpha-tocopherol concentrations are under genetic control in healthy families.
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Banco de datos:
MEDLINE
Asunto principal:
Vitamina A
/
ADN
/
Familia
/
Alfa-Tocoferol
/
Dieta
/
Ambiente
/
Antioxidantes
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2005
Tipo del documento:
Article