Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists.
Bioorg Med Chem Lett
; 15(13): 3229-32, 2005 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-15936190
ABSTRACT
High throughput screening of the corporate compound collection led to the discovery of a novel series of substituted aminoalkoxybenzyl pyrrolidines as human urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that led to the identification of a truncated sub-series, represented by SB-436811 (1a), are described.
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Banco de datos:
MEDLINE
Asunto principal:
Pirrolidinas
/
Receptores Acoplados a Proteínas G
Límite:
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article