A cost comparison analysis of partial versus whole-breast irradiation after breast-conserving surgery for early-stage breast cancer.
Int J Radiat Oncol Biol Phys
; 62(3): 790-6, 2005 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-15936561
ABSTRACT
PURPOSE:
To assess, if and for whom, there are cost savings associated with alternate breast radiotherapy (RT) techniques when compared with the conventional external beam-based whole-breast RT with a boost (WBRT-B). METHODS AND MATERIALS Treatment planning and delivery utilization data were modeled for eight different breast RT techniques (1) WBRT-B 60 Gy in 30 fractions; (2) WBRT 50 Gy in 25 fractions; (3) WBRT-accelerated (AC) 42.5 Gy in 16 fractions; (4) WBRT-intensity-modulated RT (IMRT) 60 Gy in 30 fractions; (5) accelerated partial breast irradiation (APBI)-IC, MammoSite 34 Gy in 10 twice-daily fractions; (6) APBI-IT, HDR interstitial 34 Gy in 10 twice-daily fractions; (7) APBI three-dimensional conformal RT (3D-CRT) 38.5 Gy in 10 twice-daily fractions; or (8) APBI-IMRT 38.5 Gy in 10 twice-daily fractions. Costs incurred by payer (i.e., direct medical costs; 2003 Medicare Fee Schedule) and patient (i.e., direct nonmedical costs; time and travel) were estimated. Total societal costs were then calculated for each treatment approach.RESULTS:
Not all efforts to reduce overall treatment time result in total cost savings. The least expensive partial breast-based RT approaches were the external beam techniques (APBI-3D-CRT, APBI-IMRT). Any reduced cost to patients for the HDR brachytherapy-based APBI regimens were overshadowed by substantial increases in cost to payers, resulting in higher total societal costs; the cost of HDR treatment delivery was primarily responsible for the increased direct medical cost. For the whole breast-based RT approaches, treating without a boost (WBRT) or with WBRT-AC reduced total costs. Overall, WBRT-AC was the least costly of all the regimens, in terms of costs to society; APBI approaches, in general, were favored over whole-breast techniques when only considering costs to patients.CONCLUSIONS:
Based on societal cost considerations, WBRT-AC appears to be the preferred approach. If one were to pursue a partial-breast RT regimen to minimize patient costs, it would be more advantageous from a societal perspective to pursue external beam-based approaches such as APBI-3D-CRT or APBI-IMRT in lieu of the brachytherapy-based regimens.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Costos de la Atención en Salud
Tipo de estudio:
Health_economic_evaluation
Límite:
Female
/
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article