Analysis of phenoxymethylpenicillin potassium by capillary electrophoresis.
J Chromatogr A
; 1087(1-2): 197-202, 2005 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-16130714
ABSTRACT
The application of capillary electrophoresis for separation of penicillin V and its impurities was investigated. The phosphate-borate buffer supplemented with sodium dodecyl sulfate (SDS) 20.0 g/L (69 mM) and pentanesulfonic acid sodium salt (PS) 2.2 g/L (12.5 mM) adjusted to pH 6.3, and current voltage 15 kV seem to provide optimal conditions for this aim. The resolution between penicillin V and each impurity was very good. The statistical analysis of phenoxymethylpenicillin V assay showed no significant differences between the results obtained by CE and HPLC methods.
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Banco de datos:
MEDLINE
Asunto principal:
Penicilina V
/
Electroforesis Capilar
Idioma:
En
Año:
2005
Tipo del documento:
Article