Lipid-drug interaction: a structural analysis of pindolol effects on model membranes.
Biochim Biophys Acta
; 1107(1): 165-74, 1992 Jun 11.
Article
en En
| MEDLINE
| ID: mdl-1616918
ABSTRACT
The ternary system constituted by distearoylphosphatidylcholine, pindolol (a vasodilator drug) and water has been investigated by using X-ray diffraction and calorimetric techniques. The structural modifications induced by the drug have been determined and a possible interaction model has been derived. In particular, the pindolol content-temperature dependent phase diagram shows the occurrence of two new phases the first is an interdigitated gel, and the second is a lamellar structure presenting an unusual mixed disordered-ordered conformation of the hydrocarbon chains (L alpha beta). The comparative analysis of electron density profiles relative to the L alpha beta phase, reveals significant modifications in the paraffinic region of the lipid layer. In agreement with thermodynamic results, the structural data suggest that the drug induces a stiffening and a tightening of the hydrocarbon chains. Moreover, the hydrophilic properties of the membrane (particularly in P beta, and L alpha beta phases) present an evident dependence with the drug concentration.
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Banco de datos:
MEDLINE
Asunto principal:
Pindolol
/
Membrana Dobles de Lípidos
Idioma:
En
Año:
1992
Tipo del documento:
Article