Identification of large ancient duplications associated with human gene deserts.
Nat Genet
; 37(10): 1041-3, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-16186813
ABSTRACT
We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.
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Banco de datos:
MEDLINE
Asunto principal:
Genoma Humano
/
Evolución Molecular
/
Genes Duplicados
/
Duplicación de Gen
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article