[Association between serum markers for celiac and thyroid autoimmune diseases]. / Associação entre marcadores sorológicos de doença celíaca e das doenças autoimunes da tireóide.
Arq Bras Endocrinol Metabol
; 49(4): 542-7, 2005 Aug.
Article
en Pt
| MEDLINE
| ID: mdl-16358083
ABSTRACT
Celiac disease (CD) is an autoimmune disease of the small bowel characterized by a strong genetic association with HLA - DQ2 and DQ8. Gluten is the etiological factor and the tissue enzyme transglutaminase (TGase) is its autoantigen. CD is associated with several autoimmune diseases such as type 1 diabetes, systemic lupus erythematous, rheumatoid arthritis, Sjögrens syndrome and autoimmune thyroid diseases. The aim of this study was to investigate the occurrence of serum IgA anti-endomysial and anti-human TGase antibodies in individuals with positive anti-thyroid antibody (ATA). The concordance between these two tests was also evaluated. Anti-endomysial antibodies were positive in 10 out of 456 (2.2%) and anti-human TGase were positive in 14 of 454 (3.1%) individuals with positive ATA. In control subjects they were positive in 1 of 197 (0.5%) and 2 of 198 (1%) for anti-endomysial and anti-human tissue TGase antibodies, respectively. The odds ratio (OR) for the anti-endomysial antibodies was 4.42 and for the anti-human TGase 3.12 in individuals with ATA when compared with controls. An elevated concordance index (k= 0.84) was observed between anti-endomisyal antibodies and anti-human TGase. We conclude that the determination of anti-TGase antibodies is a good test for DC screening.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Enfermedades de la Tiroides
/
Inmunoglobulina A
/
Enfermedad Celíaca
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Pt
Año:
2005
Tipo del documento:
Article