Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping.
Am J Hum Genet
; 78(3): 498-504, 2006 Mar.
Article
en En
| MEDLINE
| ID: mdl-16465623
ABSTRACT
Selective genotyping is used to increase efficiency in genetic association studies of quantitative traits by genotyping only those individuals who deviate from the population mean. However, selection distorts the conditional distribution of the trait given genotype, and such data sets are usually analyzed using case-control methods, quantitative analysis within selected groups, or a combination of both. We show that Hotelling's T(2) test, recently proposed for association studies of one or several tagging single-nucleotide polymorphisms in a prospective (i.e., trait given genotype) design, can also be applied to the retrospective (i.e., genotype given trait) selective-genotyping design, and we use simulation to demonstrate its improved power over existing methods.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proyectos de Investigación
/
Desequilibrio de Ligamiento
/
Interpretación Estadística de Datos
/
Sitios de Carácter Cuantitativo
/
Escala de Lod
Límite:
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article